The yeastSaccharomyces cerevisiaedoes not sequester chloride but can express a functional mammalian chloride channel
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چکیده
منابع مشابه
Functional reconstitution of a chloride channel bares its soul.
Chloride channels have been called the poor cousins of the aristocratic cation channels because their physiological functions involve “cleaning up the mess after the party” (1). Although Cl channels are not as glamorous as the Na, Ca, and K channels dominating neuronal signaling, their functions are indispensable (2), as exemplified by cholera caused by superactivation of a Cl channel (CFTR) in...
متن کاملChorda tympani nerve transection disrupts taste aversion learning to potassium chloride, but not sodium chloride.
In Experiment 1, rats with chorda tympani nerve transection (CTX) acquired a LiCl-conditioned taste aversion to 0.1 M NaCl at the same rate as controls. After 3 conditioning trials, the aversion generalized to 0.03 and 0.3 M NaCl, but did not generalize to KCI (0.03, 0.1, and 0.3 M), in either the sham or CTX group. In Experiment 2, the sham group, but not the CTX group, formed an aversion to 0...
متن کاملA novel chloride channel localizes to Caenorhabditis elegans spermatids and chloride channel blockers induce spermatid differentiation.
Caenorhabditis elegans spermatogenesis is especially suited for studies of nonrandom cytoplasmic segregation during cellular differentiation. Spermatocytes separate from an anuclear cytoplasmic core and undergo two sequential divisions. During the second division, intracellular organelles segregate specifically to spermatids as they bud from an anuclear residual body. We have applied patch-clam...
متن کاملMyotonia levior is a chloride channel disorder.
The group of dominant non-dystrophic myotonias, comprising disorders characterized by clinically similar forms of myogenic muscle stiffness, is genetically inhomogeneous. Dominant myotonia congenita (Thomsen's disease) is linked to CLCN1, the gene encoding the major muscle chloride channel, localized on chromosome 7q35. In contrast, dominant myotonias sensitive to potassium are caused by point ...
متن کاملTransmembrane topology of a CLC chloride channel.
CLC chloride channels form a large and conserved gene family unrelated to other channel proteins. Knowledge of the transmembrane topology of these channels is important for understanding the effects of mutations found in human myotonia and inherited hypercalciuric kidney stone diseases and for the interpretation of structure-function studies. We now systematically study the topology of human Cl...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 1999
ISSN: 0378-1097,1574-6968
DOI: 10.1111/j.1574-6968.1999.tb08745.x